Takashi Ikejima Selected Research

RNA (Ribonucleic Acid)

12/2018	Persistent IKKα phosphorylation induced apoptosis in UVB and Poly I:C co-treated HaCaT cells plausibly through pro-apoptotic p73 and abrogation of IκBα.
1/2018	Sub-lethal ultraviolet B irradiation and Poly I:C treatment synergistically induced apoptosis of HaCaT cells through NF-κB pathway.

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Takashi Ikejima Research Topics

Disease

30	Melanoma (Melanoma, Malignant) 01/2017 - 04/2002
28	Neoplasms (Cancer) 04/2024 - 01/2003
24	Fibrosarcoma 09/2017 - 03/2004
16	Breast Neoplasms (Breast Cancer) 04/2024 - 05/2007
10	Inflammation (Inflammations) 01/2020 - 04/2010
9	Mitochondrial Diseases (Mitochondrial Disease) 01/2023 - 12/2006
9	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/2007 - 01/2003
8	Lymphoma (Lymphomas) 03/2024 - 03/2005
8	Squamous Cell Carcinoma (Epidermoid Carcinoma) 06/2013 - 01/2007
8	Carcinoma (Carcinomatosis) 09/2012 - 12/2007
7	Necrosis 09/2008 - 09/2003
5	Bites and Stings (Sting) 01/2023 - 01/2021
5	Liver Diseases (Liver Disease) 08/2022 - 09/2006
4	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 01/2012
4	Cognitive Dysfunction 01/2023 - 03/2010
4	Type 2 Diabetes Mellitus (MODY) 01/2023 - 06/2018
4	Neuroinflammatory Diseases 01/2023 - 04/2017
4	Lung Neoplasms (Lung Cancer) 10/2017 - 01/2012
3	Autosomal Dominant Optic Atrophy (Dominant Optic Atrophy) 04/2022 - 01/2019
3	Parkinson Disease (Parkinson's Disease) 11/2021 - 09/2021
3	Fibrosis (Cirrhosis) 01/2020 - 07/2018
3	Adenocarcinoma 01/2007 - 03/2004
2	Diabetes Mellitus 08/2018 - 01/2012
2	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 02/2018 - 01/2018
2	Laryngeal Neoplasms (Laryngeal Cancer) 12/2015 - 08/2010
2	Starvation 09/2014 - 05/2007
2	Pheochromocytoma 09/2012 - 07/2011
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2012 - 01/2012
1	Insulinoma 01/2023
1	Amyloid Plaque 01/2023

Drug/Important Bio-Agent (IBA)

47	Silybin (Lagosa)IBA 04/2024 - 09/2006
31	oridoninIBA 12/2015 - 06/2004
16	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2013 - 10/2007
14	CaspasesIBA 01/2020 - 09/2003
13	Proteins (Proteins, Gene)FDA Link 01/2023 - 12/2006
12	evodiamineIBA 07/2010 - 01/2003
10	DiterpenesIBA 10/2017 - 06/2004
9	pseudolaric acid BIBA 10/2017 - 12/2004
8	Nitric Oxide (Nitrogen Monoxide)FDA Link 09/2014 - 01/2008
5	CollagenIBA 03/2024 - 01/2018
5	Collagen Type I (Type I Collagen)IBA 03/2024 - 02/2015
5	Small Interfering RNA (siRNA)IBA 01/2023 - 01/2019
5	FlavonoidsIBA 10/2017 - 07/2004
5	SilymarinIBA 11/2012 - 07/2004
5	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2012 - 02/2007
4	GelatinIBA 03/2024 - 01/2016
4	DNA (Deoxyribonucleic Acid)IBA 01/2023 - 06/2003
4	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 10/2017
4	Amyloid (Amyloid Fibrils)IBA 01/2020 - 07/2011
4	AcidsIBA 10/2017 - 07/2005
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2016 - 12/2005
4	ErbB Receptors (EGF Receptor)IBA 11/2012 - 02/2007
3	AntioxidantsIBA 01/2023 - 04/2010
3	LipidsIBA 01/2023 - 08/2018
3	InterferonsIBA 01/2023 - 01/2021
3	Dynamins (Dynamin)IBA 04/2022 - 01/2019
3	Insulin (Novolin)FDA Link 01/2022 - 06/2018
3	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 11/2021 - 09/2021
3	Phosphotransferases (Kinase)IBA 01/2020 - 04/2005
3	JNK Mitogen-Activated Protein KinasesIBA 09/2018 - 09/2008
3	physalin AIBA 09/2014 - 05/2013
3	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneIBA 11/2013 - 12/2005
3	Cytochromes c (Cytochrome c)IBA 12/2012 - 04/2009
3	norcantharidinIBA 01/2012 - 08/2004
3	Insulin-Like PeptidesIBA 04/2010 - 07/2008
3	Sirtuin 1IBA 03/2007 - 04/2005
2	phorbolIBA 03/2024 - 11/2019
2	Myristic Acid (Tetradecanoic Acid)IBA 03/2024 - 11/2019
2	Neuroprotective AgentsIBA 01/2023 - 01/2023
2	Palmitic Acid (Hexadecanoic Acid)IBA 01/2023 - 10/2019
2	3- (2,4- dichloro- 5- methoxyphenyl)- 2- sulfanyl- 4(3H)- quinazolinoneIBA 01/2023 - 01/2019
2	Streptozocin (Streptozotocin)FDA Link 01/2023 - 01/2012
2	Matrix Metalloproteinases (MMPs)IBA 01/2023 - 09/2021
2	Adenosine Triphosphate (ATP)IBA 01/2023 - 01/2019
2	Mitochondrial DNA (mtDNA)IBA 01/2023 - 01/2020
2	Interferon Regulatory Factor-3 (Interferon Regulatory Factor 3)IBA 11/2021 - 01/2021
2	PPAR gammaIBA 01/2020 - 01/2019
2	mitochondrial transcription factor AIBA 01/2020 - 01/2019
2	Estrogen Receptor alphaIBA 10/2019 - 07/2015
2	Pattern Recognition ReceptorsIBA 12/2018 - 01/2018
2	Toll-Like Receptor 3IBA 12/2018 - 01/2018
2	RNA (Ribonucleic Acid)IBA 12/2018 - 01/2018
2	bis-benzimidazoleIBA 01/2016 - 10/2012
2	Antineoplastic Agents (Antineoplastics)IBA 12/2015 - 04/2010
2	Caspase 9IBA 12/2015 - 08/2004
2	RTKI cpdIBA 11/2012 - 08/2010
2	Nitroprusside (Sodium Nitroprusside)FDA LinkGeneric 09/2012 - 07/2011
2	Mitomycin (Mitomycin-C)FDA LinkGeneric 05/2011 - 10/2009
2	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 09/2008 - 12/2005
2	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 09/2008 - 01/2004
2	Sepharose (Agarose)IBA 12/2005 - 08/2005
2	shikoninIBA 04/2005 - 02/2004
1	IronIBA 01/2023
1	InflammasomesIBA 01/2023
1	Acetylcysteine (Siran)FDA LinkGeneric 01/2023
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2023
1	Caspase 1 (ICE Protease)IBA 01/2023

Therapy/Procedure

6	Therapeutics 04/2024 - 05/2008
2	Aftercare (After-Treatment) 04/2009 - 09/2008
1	Traditional Medicine (Folk Remedies) 04/2022